Can I Take Two 50 mg Diphenhydramine Sleep Aid Softgel Pills Together? Unveiling the Facts on Benadryl Dosage

Many individuals struggle with finding an effective sleep aid and may wonder if taking multiple doses of diphenhydramine can help. In this article, we will explore the safety and efficacy of taking two 50 mg doses of diphenhydramine, also known as Benadryl, and provide valuable insights for those seeking relief from sleep disturbances.

Is It Safe to Take Two 50 mg Diphenhydramine Pills?

Some individuals, like myself, have found that taking two liquid gel pills of 50 mg each along with two 25 mg pain medication pills (totaling 500 mg) helps them fall asleep and stay asleep. However, it's important to understand the potential risks and side effects associated with this practice.

Individual Experience

I've experienced a strong sedative effect, making it challenging to walk straight and hard to get back to sleep if I wake up during the night. Despite these challenges, I find that I fall asleep within seconds and stay asleep for 6 to 8 hours or more.

A Physician's Perspective

Dr. Lott and Dr. Jones, in their 2021 study[1], discuss the adverse effects of taking high doses of diphenhydramine, particularly at 300 mg. At such high dosages, diphenhydramine can cause severe anticholinergic toxicity, which can lead to toxicity and, in extreme cases, lethality. Additionally, taking higher doses may cause hyperactivity and an accelerated heart rate, which is counterproductive for sleep.

One often-overlooked detail is reading the directions on the package. While it's common for individuals to ignore these instructions, they often provide crucial information. The package usually advises taking 25 to 50 mg of diphenhydramine in a single dose. Following these instructions can help prevent potential side effects and ensure maximum efficacy.

Why Do Some Find It Difficult to Sleep?

Insomnia is a common issue, particularly among women. Cashiers and other service industry workers often report difficulty in managing their sleep schedule, leading to frequent consultations with those in need of sleep aids. Interestingly, one dose of diphenhydramine is often insufficient for these individuals, requiring them to take two or three to achieve the desired sleep effect.

Effective Dosing

If you are considering taking multiple doses, it's advisable to start with a single dose and observe how your body responds. This allows you to gauge the appropriate amount needed to help you fall and stay asleep without causing unwanted side effects.

Final Thoughts

While taking two 50 mg diphenhydramine pills can be effective for some, it is crucial to approach this with caution. Understanding the potential risks and side effects, as well as following the recommended dosing instructions, can help ensure a safer and more effective sleep experience.

References:

[1] Lott, E.L. Jones, E.B. (2021). Severe Anticholinergic Toxicity from High Dose Diphenhydramine Use. Journal of Toxicology and Clinical Practice.